How Enzymes Affect Our Physical and Mental Health

Enzymes are involved in the formation and composition of every cell in the body. Thus they also control the working of every organ and even the brain – the control center. They are involved in the breakdown, absorption, distribution and circulation of various nutrients entering the body. Overall, it would be sufficient to say that life would be non-existent without enzymes.

How many of us have ever been concerned about our gut health and how enzymes affect the digestive process. It obviously is the last thing that one would care about after a whole busy day and the same regular stressing lifestyle. People will not pay attention to this until it is serious enough to cause severe health problems.

Alcohol, coffee, artificial carbohydrates and sugars reduce the secretion of enzymes. Under the current high-intensity work and life pressure, we rely more on fast food and less focus on the balance of diet. With disease, age, pregnancy, and several other conditions, the production of important enzymes in the body decreases.

Most of the times older people suffer from being full even after hours they had taken their meal. The reason may be the formation of gas, diarrhea, constipation and low protein tolerance. There are enough proteins present in the food too but cooking in modern ways destroys the element. Therefore, no matter what you eat, you are actually eating something without nutrition, which obviously cannot meet the needs of the human body. When cooked food is waiting for enzymes in the stomach, harmful bacteria and other parasites form in the food and cause disease. Doctors today often recommend that patients should contain natural digestive enzymes in their diet, such as protease andlipase.

When the food moves into the intestine, it is neutralized by the secretions (mainly including pepsin and pancreatin) from the pancreas and liver. If this is not done, as in the case of people with damaged liver (out of age, alcohol consumption, illness, and other factors) ulcers and millions of other problems could occur.

Each enzyme is responsible for performing a specific task efficiently, and the others need to be perfectly balanced. Lack of a certain enzyme will definitely interfere in the working of another and this makes a chain altogether. Our body has over 2,300 enzymes and yet more are to be discovered.

Brain chemistry is by far the most complex of processes and affects every single part of the body. Hormones that are triggered by chemical reactions facilitate a complex chain of reaction that is again controlled by the brain. Even “falling in love at first sight” is the work of the brain and the subsequent enzyme that feeds the reactions. Upon birth, the human body produces the enzymes required to balance the child to the new environment. However, as the child learns and adapts, the production of certain enzymes decreases. An individual’s potential is directed by genes that he/she inherits from the parents. This way, some are blessed enough to have high mental potential, while some have the low mental capability.

When there is a deficiency of a certain enzyme in the brain chemistry, what do you think would happen to this person? The fastest solution will be to understand, try and balance the deficiency. Abnormal brain chemistry can lead to serious mental problems. The root of the problem in most cases in lack of nutrients and facilitating enzymes. The sufficient supply of enzymes can break down proteins, fats, fiber, carbohydrates that get into the body and help in absorption, distribution and the subsequent elimination of wastes. Toxins, if carried with the blood can cause serious problems, and over 20 years of research has proved some enzyme supplements can help in mental conditions too.

How to Pick the Right Percussion Massager for you

While watching sports, you may have observed that athletic trainers carry a device during games that look similar to a jigsaw, using it on players while they are on sidelines or bench. This type of device is percussion massager, and this amazing device produces a series of rapid movements that punches into the body and penetrates deep into the muscles and tissue. The punches help in promoting relaxation, tissue repair and pain relief for the players’ thereby improving range-of-motion and blood flow in their muscles. Earlier, these percussive motions are only available through a physical therapist or masseuse, but now it is possible to do get relaxation with a small handheld device. So, how will you know which is the right percussion massager for you? Read till the end.

Working of a Percussion Massager

It is a foam ball or any other accessory attached to a piston and moved by a battery-powered motor. These massagers run anywhere from 1400 to 3300 rpm depending on the model and allow for powerful strikes and precision to soft tissue on different body parts at the right frequency. Due to the frequency they operate and the strength of the handheld devices, they penetrate deeper into the muscle than hands alone.

Features

There are a lot of features available depending on the model you want to buy.

Massage Heads

A professional percussion manager will be having a set of interchangeable massage heads that are specially designed for different body parts. The round head is the most common head for large muscle groups. Another head is the flat one that is generally used for smaller parts of the body. For specific muscle groups like the spine, neck, and the Achilles tendon, forkhead is used. For deep tissue, joints, and trigger points on the body, the bullet head is used.

Variable Speed

There are models that offer variable speed, but some do not offer. A percussion massager having a wide range of speeds offers more flexibility of use. The widest ranges for professional models are available from 1400 to 3300 rpm.

The life span of Battery

As these massagers are portable and handheld, you must find one that has long battery life. Most sets of use for these massagers are for 15 seconds to a minute with multiple repetitions, but you want to work on different parts of your body so, you want a massager that lasts the full massage session.

Noise

Depending on the model, a percussion massager can be noisy, so depending on where you are using, you need to find an ultra-quiet massager in the market for more convenience.

Portability

These handheld devices require a proper way of carrying it around with its accessories, so a convenient handheld case that will protect the device is a great addition to a premium product.

Whether you are recovering from an injury or a sports person, a percussion massager helps in speeding up your recovery time, but it will be wise to consult a doctor if you have any problems with using this device on certain injuries.

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Most brands of oxycodone are not approved for use in people under 18. OxyContin should not be given to a child younger than 11 years old.

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a head injury, or seizures;
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urination problems; or
problems with your gallbladder, pancreas, or thyroid.
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cRGDfK-Grafted Small-Size Quercetin Micelles For Enhancing Therapy Efficacy Of Active Ingredient

As an active ingredient of Chinese herbal medicine, quercetin (QU) can significantly induce apoptosis of tumor cells and give play to other effect such as decreasing both fibroblast population and collagen in cancer cell nest. However, the antitumor efficacy of quercetin was mostly evaluated at cellular level and rarely developed in vivo by intravenous injection, which may be ascribed to its inferior physicochemical properties including water insolubility, short plasma half-time, and insufficient enrichment in the tumor tissues.

The DSPE-PEG was used to construct quercetin-loaded micelles, and the integrin ligand cRGDfK was grafted to modify the nanocarrier for enhancing its cancer-specific homing. The MALDI-TOF-MS, DLS, TEM, and UV were orderly operated to characterize guidance molecules and micelles by morphology, size distribution, Zeta potential, and drug encapsulation efficiency. In addition, the surface plasmon resonance study and real-time confocal analysis were employed to demonstrate αvβ3 integrin-overexpressing B16 cells-specific binding and uptake. After further pharmacodynamics studies in vitro and in vivo, we also evaluate systemic toxicity about cRGDfK-PM-QU.

The cRGDfK was successfully stitched with DSPE-PEG and modified on the surface of micelles. The ligand modification enhanced the negative charges of the micelles, but it did not induce significant changes in particle size. The quercetin micelles were about 15 nm in size and negatively charged, and had spherical morphology and high drug encapsulation efficiency. In vitro, the cRGDfK-modified micelles (cRGDfK-PM) showed αvβ3 integrin-overexpressing B16 cells-specific binding and uptake, and cRGDfK-PM-QU (QU loaded in cRGDfK-PM) induced more significant cell apoptosis and cytotoxic effects against B16 tumor cells than counterpart micelles (PM-QU). In vivo, the cRDGfK modification enhanced enrichment in B16 tumor tissue, improved the therapeutic efficacy of the quercetin-loaded micelles against B16 tumor, and exhibited lower systemic and pulmonary toxicity compared with counterpart micelles in the mouse mode.

Quercetin as a natural product has triggered increasing interest in the antitumor field. In this study, cRGDfK-modified DSPE-PEG micelles significantly optimized quercetin therapeutic efficacy and pulmonary toxicity as well as lowered systemic toxicity.